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Two types of coumarins-specific enzymes complete the last missing steps in pyran- and furanocoumarins biosynthesis

2023-10-31

Two types of enzymes that mediate prenylation and cyclization reactions, respectively are identified. These newly discovered enzymes complete the last missing steps in linear/angular PC and FC biosynthesis. The acid/base-assisted epoxide ring opening mediated the chemical diversity and the formation of disfavored 6-endo-tet cyclization products further expanding our knowledge regarding the classical Baldwin’s rules. 

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